The San Francisco 49ers are set to host the Detroit Lions at Levi’s Stadium in Santa Clara, California, on Monday, December 30, at 5:15 p.m. PT. The Lions enter the contest as 3.5-point favorites.
Each week, 49ers Webzone staff members participate in the NFL Pick ’em contest, predicting the winners of every game. For Week 17, none of the seven participating staff members have chosen the 49ers to upset the Lions.
Fan predictions echo that sentiment. As of this post, 81 percent of fans participating in the NFL Pick ’em contest have picked the Lions to emerge victorious.
Most One-Sided Matchup: Jets at Bills
The most lopsided prediction of the week comes from Sunday’s matchup between the New York Jets and the Buffalo Bills. A unanimous 100 percent of participants expect the Bills to dominate and secure the win.
Most Competitive Matchup: Titans at Jaguars
In contrast, the tightest race in the predictions belongs to Sunday’s game between the Tennessee Titans and the Jacksonville Jaguars. With 57 percent of participants picking the Jaguars.
Week 17 NFL Matchups
Below is a breakdown of the remaining 12 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
| 98% | Chargers | Patriots | 2% |
| 15% | Broncos | Bengals | 85% |
| 94% | Colts | Giants | 6% |
| 0% | Jets | Bills | 100% |
| 38% | Raiders | Saints | 62% |
| 3% | Panthers | Buccaneers | 97% |
| 43% | Titans | Jaguars | 57% |
| 4% | Cowboys | Eagles | 96% |
| 78% | Dolphins | Browns | 22% |
| 35% | Packers | Vikings | 65% |
| 7% | Falcons | Commanders | 93% |
| 81% | Lions | 49ers | 19% |