James Hawkins: The Cardinals have arguably been the best road team in the NFL this season and they should have no problem finding any offensive success, even without star receiver DeAndre Hopkins. The Lions don’t have the pieces to keep up with one of the league’s top-scoring offenses, a task that’s even more difficult when you consider Arizona is holding foes under 20 points per game. While the Lions are an easy opponent to overestimate, the Cardinals should have few difficulties and cruise to a comfortable win. Cardinals, 30-13
John Niyo: The Lions will have a chance to win another game before this season is over, though this probably isn’t it. Still, the Cardinals are making a long road trip off a tough loss with a short week of practice. So maybe the Lions can catch them flat-footed early and keep this one close, as they’ve done quite a few times. The Lions are 1-11-1 in the standings, but they’re above .500 (7-5) against the spread. I’ll say they make it 8-5, barely. Cardinals, 27-17
Justin Rogers: If the Broncos rolling the Lions by 28 points told us anything, it’s that this roster isn’t built to remain competitive under the strain of its current issues. It’s admittedly unclear whether the league’s adjustment to its COVID policies will allow Detroit to get any additional players back, but odds remain the defense, particularly the secondary, will be significantly undermanned against one of the NFL’s more potent offensive attacks. And lets face it, the Lions aren’t equipped to go toe-to-toe with that kind of firepower, particularly with their two best offensive weapons, tight end T.J. Hockenson and running back D’Andre Swift, sidelined. We appear primed to witness a pummeling. Cardinals 29, Lions 13
Bob Wojnowski: As the weeks dwindle and injuries mount, it’s harder to find another win anywhere for the Lions. Their only hope here is if Kyler Murray is loose again with the football — he has nine interceptions — and the Cardinals can’t overcome the loss of WR DeAndre Hopkins. Jared Goff has done a decent job finding receivers, such as Amon-Ra St. Brown, but just lost tight end T.J. Hockenson. Oh, and the Cardinals’ defense ranks fifth in the league. Oh, and at 10-3 they’re now in a tussle for the NFC West lead with the Los Angeles Staffords. Oh, and they’re 7-0 on the road. Oh, no. Cardinals, 31-10